When you purchase through links on our site , we may gain an affiliate commission . Here ’s how it act .
More may not always be good when it amount to vitamin D.
A Modern study from Denmark bump that mellow levels of vitamin D in the rip are linked with an increased risk of some cancer — but a decreased risk of others .
Specifically , the researchers detect that high vitamin five hundred levels were linked with an increased risk of skin , prostate gland and stock cancer , and a decreased risk oflung genus Cancer .
The field of study found only an association ; it can not shew that gamey vitamin D stage cause or forbid sure cancers . Nor can the cogitation determine the precise reason for these seemingly contradictory effects on malignant neoplastic disease risk of exposure .
But the researchers hope the findings draw attention to the possibility thathigh vitamin vitamin D levelsaren’t always a adept thing . Until now , much of the research on vitamin D and cancer has been focused on the effects of low vitamin 500 levels , said study lead author Dr. Fie Juhl Vojdeman , of the Department of Clinical Biochemistry at Bispebjerg Frederiksberg Hospital in Copenhagen , Denmark . [ 10 Do ’s and Don’ts to boil down Your Risk of Crab ]
People " have the impression that they can exhaust all the [ vitamin D supplements ] they need without any concerns , " Vojdeman told Live Science . " However , we in reality do n’t love whether it could be harmful in the long runnel to use gravid doses of [ vitamin D supplement ] if you do not have a critically low level in the stemma . "
Vojdeman said more research is needed on the link between high vitamin 500 levels and Crab .
Thefindings were presentedMonday ( April 16 ) at the American Association for Cancer Research merging in Chicago and have not yet been published in a peer - reviewed daybook .
For the study , the researchers analyse datum from more than 200,000 people go in the Capital Region of Denmark ( a region in eastern Denmark ) who had their blood vitamin D levels measured between April 2004 and January 2010 . ( Specifically , the researchers looked at the spirit level of 25OH vitamin D , or 25 - hydroxyvitamin D , a metabolite of the vitamin that ’s used as a quantity of its levels in the body . ) None of the participants had been diagnosed with Cancer the Crab prior to their vitamin D test . The participant were followed for up to 10 years .
The average vitamin D measurement was about 50 nanomoles per liter ( nmol / L ) . Normal levels are between 50 and 125 nmol / L ( or 20 to 50 nanograms / milliliter ) , according tothe National Institutes of Health ’s Office of Dietary Supplements .
During the study follow - up catamenia , more than 18,000 citizenry in the study were diagnose with cancer . The study institute that every 10 nmol / L growth in blood vitamin five hundred was associated with a 9 - percent increase in the risk of nonmelanomaskin malignant neoplastic disease , a 10 - percent increase in the risk of exposure of melanoma , a 5 - pct increase in the peril of prostate Cancer the Crab and a 3 - percent increment in the risk of lineage cancers .
But every 10 nmol / L gain in blood vitamin D was also linked with a 5 - percent diminution in the hazard of lung cancer .
The study was not project to examine the mechanism behind these links , Vojdeman noted . One opening , however , is that the higher risk of skin Crab is connect to multitude ’s Sunday photograph . ( hoi polloi ’s dead body make vitamin ergocalciferol when disclose to sunshine , but too much sun vulnerability can lead to pelt Cancer the Crab . ) However , Vojdeman order the study did not have data on the participant ' sun trade protection .
Some studies have also found that the active metabolite of vitamin D , called calcitriol , has an immune suppressive essence that ’s also look in some cancers , Vojdeman said .
So , " theoretically , the higher level of vitamin D could excogitate a more suppressive immune regulatory surround " that ’s tie with cancer , Vojdeman said . However , she stressed that this idea is " purely speculative at the moment . "
In contrast , in written report in lab dishes , calcitriol has also been shown to counterbalance the effects of smoking on a character of lung prison cell , which might possibly explain the link with a reduce risk of lung cancer . But again , this idea need more inquiry .
at last , " there is a want for more subject area on the burden of high levels of … vitamin cholecalciferol on Cancer the Crab at the mechanistic level , " Vojdeman say .
Original article onLive scientific discipline .
