bailiwick on the safety of unpaid drugs tend to put X on thelower end of the harm weighing machine . In its purest form , and at low doses , MDMA is often said to be one of theleast life-threatening drug – at least in comparison to other wide available drugs like alcoholic beverage and baccy .
However , as one particularly ( ok , highly ) unusual case study appearance , long - full term habit of excessive amounts of the drug can have lasting harmful and unpleasant side effects .
A team of doctor at St George ’s Medical School , London , reported on the caseof " Mr A " , a 37 - year - former who had used Adam in vast quantities between the ages of 21 and 30 . For the first two old age of using the drug , he was taking five tablets every weekend . Over the next three years , he start out to habituate an norm of 3.5 tablet a day , thereafter moving to an average of 25 tab a day for the next four years .
The squad figure that over these nine years , he had taken over 40,000 tablets – 38,000 above the antecedently record lifetime aspiration record of 2,000 pills . The use was corroborated by notation from another servicing he had attended years prior .
" For a few months , he felt as if he was still under the influence of ecstasy and suffer several instalment of ' burrow vision . ' , " the team wrote in thereport . " He finally develop severe panic attack , recurrent anxiousness , economic crisis , musculus rigidness ( particularly at the neck opening and jaw level ) , functional hallucination , and paranoid ideation . "
As well as convey ecstasy , the human race had a story of using solution , benzodiazepines , amphetamines , LSD , cocain , heroin , and cannabis , though at the time of his entrance fee to St George ’s Hospital the only drug he was presently using was cannabis .
" appraisal of daily function science identified major behavioral consequences of his memory passing ( i.e. , repeating activities several time ) . Although Mr. A was able to fully understand the instructions given , his concentration and attention were so impaired that he was unable to come the episode of the tasks required . "
The squad consider him to have a spherical memory - mathematical function disability and he was give MRI CAT scan , though these revealed no structural issues with his head . His memory better watch over his entrance fee to a brain injury unit of measurement , where he learned compensation strategies .
However , the team conceive that the case added to evidence that impairment triggered by prolong go habit were not reversed by withdrawing the drug for prospicient periods of time .
" All Adam misusers would get a ( mild - degree , in most cases ) serotonin syndrome after acute drug intake , which is characterized by enhanced forcible activity , hyperthermia and sweating , increased musculus rigidity , rhabdomyolysis , hyperreflexia , trismus , jaw - clenching , myoclonus , earth tremor , and nystagmus , " the team save in the report .
Though these are symptoms of acute intoxication , they could explicate why Mr A was left with muscle inflexibility – particularly in his jaw – after such prolonged high-pitched - dose utilization of the drug .
The tunnel visual sensation he report shortly after withdrawing from MDMA use was singular as far as the squad is cognisant , and is thus far unexplained .
