According to novel research publish inPLOS Genetics , fathers can pass a genetic variation that increases the risk of ovarian cancer to their daughter . A squad of scientists from the Roswell Park Cancer Institute ( RPCI ) found that a freshly discover genetic mutation is touch base to early onslaught of ovarian cancer in charwoman and prostate genus Cancer in fathers and Son because it is passed down through the father ’s X - chromosome .
former inquiry has show that when a woman gets ovarian Crab , her sister has a high endangerment of developing the disease than their mother , suggest that perhaps this genetic predisposition is pass along down from the sire . So Kunle Odunsi and Kevin H. Eng from the RPCI resolve to investigate the role of the founder ’s X - chromosome .
To research this , the scientists looked at data on 3,499 granddaughter / grandmother pairs from the RPCI ’s Familial Ovarian Cancer Registry , finding 892 informatory pairs and 157 granddaughters affected by ovarian cancer . They also sequenced office of the X - chromosome of 186 char with ovarian Crab . The squad discovered that ovarian Crab can be inherited from the paternal grandmother , and that those with the familial mutation are more likely to get the genus Cancer early – around six years earlier than modal . to boot , the Father in - between were chance to be more potential to get prostate gland Crab if their female parent had had ovarian cancer .
The squad also reveal that the gene on the ex - chromosome can increase the chances of a woman start ovarian cancer regardless of the presence of other known susceptibility genes likeBRCA genes .
“ Our sketch may explain why we find mob with multiple affected daughter : because a dad ’s chromosome determine the sex of his children , all of his daughter have to persuade the same 10 - chromosome gene , ” said Eng in astatement , adding that more research is call for to ensure the right gene was identify .
“ This finding has spark a lot of discourse within our radical about how to find these X - join families , " Eng added . " It ’s an all - or - none kind of formula : A crime syndicate with three daughter who all have ovarian Crab is more likely to be driven by inherited X mutations than by BRCA mutations . ”
